Medication 7-380 - Magnesium Sulfate

Polk, Hickory, Cedar, & St Clair EMS Protocols

Scope of Practice:

• Registered Nurse
• Paramedic

Route(s):

• IO, IV,

Pharmacodynamics (class and mechanism of action):

• Anticonvulsant. Smooth muscle relaxer. (CNS depressant. Cofactor in neurochemical transmission and muscular excitability. Controls Seizure by blocking peripheral neuromuscular transmission. Peripheral vasodilator and platelet inhibitor.).

Pharmacokinetics:

• Half-life: Unknown.
• Onset time:
• IM: 1 hour.
• IV: 1-2 minutes.
• Peak action time: Unknown.
• Duration of action: Unknown.

• Peak	1	minutes
  Duration	1	minutes

Dosing:

• Refer to specific protocol(s) below for dose(s).

Indications:

• Protocol 2-528 - Hypertension.
• Protocol 2-770 - Respiratory Distress.
• Protocol 2-946 - Ventricular Tachycardia.
• Protocol 2-968 - V-Fib / Pulseless V-Tach.

Contraindications:

• Heart block.
• Recent MI.
• Renal insufficiency or renal failure.
• GI obstruction.

Pregnancy Risk Factor:

• Category A
• No risk in controlled human studies: Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

Potential Incompatibilities:

• None.

Precautions and Adverse Effects:

• Do not exceed 1 g per minute dose rate. Monitor for Magnesium toxicity.
• Use caution with Digitalis and hypotension.
• May cause Respiratory depression and/or drowsiness.

Antidote:

• Medication 7-100 - Calcium Chloride.
• Medication 7-240 - Glucagon.

Controlled Substance Information:

• Not a scheduled drug
• The DEA and FDA have not identified this drug with a schedule classification.
• DEA number: NA.
• Narcotic: No.
• Street names: NA.

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Polk, Hickory, Cedar, & St Clair County EMS Protocols by Theron Becker is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.