Medication 7-779 - Propofol (Diprivan)

CMH EMS & MIH Protocols

Scope of Practice:

• Registered Nurse
• Paramedic
• Community Paramedic

Route(s):

• IO, IV,

Pharmacodynamics (class and mechanism of action):

• Anesthetic. (Produces rapid and brief state of general anesthesia.)

Pharmacokinetics:

• Half-life:
• Initial phase (distribution): 2-10 minutes.
• Second phase (redistribution): 21-70 minutes.
• Terminal phase (elimination): 1.5-31 hours.
• Onset time: Less than 40 seconds.
• Peak action time: Unknown.
• Duration of action: 10-15 minutes.

• Peak	1	2	3	4	5	6	7	8	9	10	11	12	13	14	minutes
  Duration	1	2	3	4	5	6	7	8	9	10	11	12	13	14	minutes

Dosing:

• Refer to specific protocol(s) below for dose(s).

Indications:

• Not in current standing order protocols.

Contraindications:

• Hypovolemia.
• Sensitivity to soybean oil or eggs.

Pregnancy Risk Factor:

• Category B
• No risk in other studies: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women, or animal studies have shown adverse effects, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Potential Incompatibilities:

• None.

Precautions and Adverse Effects:

• May cause apnea, arrhythmias, Asystole, hypotension, and/or Hypertension.

Antidote:

• None.

Controlled Substance Information:

• Not a scheduled drug
• The DEA and FDA have not identified this drug with a schedule classification.
• DEA number: NA.
• Narcotic: No.
• Street names: NA.

CMH Pre-Hospital Services Mission: "Provide safe, exceptional, and compassionate care to our communities with an emphasis on highly trained and empowered staff."

CMH Mobile Integrated Healthcare Mission: "Provide exceptional, compassionate, and patient-centered care by a mobile collaborative team to improve patient experience, improve quality outcomes, and reduce healthcare costs."

Polk, Hickory, Cedar, & St Clair County EMS Protocols is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.