Medication 7-186 - Captopril (Capoten)

CMH EMS & MIH Protocols

Scope of Practice:

• Registered Nurse
• Paramedic
• Community Paramedic

Route(s):

• IO, IV, SL,

Pharmacodynamics (class and mechanism of action):

• ACE inhibitor (Competitive inhibitor of Angiotension Converting Enzyme).

Pharmacokinetics:

• Half-life: 1.9 hours.
• Onset time: 15-60 minutes.
• Peak action time: 60-90 minutes.
• Duration of action: 6-12 hours.

• Peak	54	108	162	216	270	324	378	432	486	540	594	minutes
  Duration	54	108	162	216	270	324	378	432	486	540	594	minutes

Dosing:

• Refer to specific protocol(s) below for dose(s).

Indications:

• Protocol 2-726 - Pulmonary Edema.

Contraindications:

• Pregnancy.
• Hypersensitivity to any ACE inhibitor.

Pregnancy Risk Factor:

• Category D
• Positive evidence of risk: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Potential Incompatibilities:

• NA.

Precautions and Adverse Effects:

• Use caution with aortic stenosis, bilateral renal artery stenosis, hypertrophic obstructive cardiomyopathy, pericardial tamponade, elevated serum potassium levels, and acute kidney failure.
• May cause hyperkalemia, especially in patients with renal deficiency.
• May cause hypotension, angioedema, headache, dizziness, fatigue, depression, Chest Pain, palpitations, cough, Dyspnea, nausea, vomiting, rash, pruritus, and/or renal failure.

Antidote:

• NA.

Controlled Substance Information:

• Not a scheduled drug
• The DEA and FDA have not identified this drug with a schedule classification.
• DEA number: NA.
• Narcotic: No.
• Street names: NA.

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Polk, Hickory, Cedar, & St Clair County EMS Protocols is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.