Medication 7-987 - Zofran (Ondansetron)

Polk, Hickory, Cedar, & St Clair EMS Protocols

Scope of Practice:

• Registered Nurse
• Paramedic

Route(s):

• IM/SQ, IN, Neb, PO, SL,

Pharmacodynamics (class and mechanism of action):

• Antiemetic (Selective Serotonin 5-HT receptor antagonist).

Pharmacokinetics:

• Half-life: 4 hours.
• Onset time: Immediate.
• Peak action time:
• IM: 41 minutes.
• IV: 10 minutes.
• Duration of action: Unknown.

• Peak	24	48	72	96	120	144	168	192	216	240	264	minutes
  Duration	24	48	72	96	120	144	168	192	216	240	264	minutes

Dosing:

• Refer to specific protocol(s) below for dose(s).

Indications:

• Protocol 2-990 - Vomiting.

Contraindications:

• Hypersensitivity.

Pregnancy Risk Factor:

• Category B
• No risk in other studies: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women, or animal studies have shown adverse effects, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Potential Incompatibilities:

• None.

Precautions and Adverse Effects:

• May prolong QT interval. 12-lead is indicated after administration.

Antidote:

• None.

Controlled Substance Information:

• Not a scheduled drug
• The DEA and FDA have not identified this drug with a schedule classification.
• DEA number: NA.
• Narcotic: No.
• Street names: NA.

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Polk, Hickory, Cedar, & St Clair County EMS Protocols by Theron Becker is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.