Medication 7-504 - Labetalol (Nomadyne)

CMH EMS & MIH Protocols

Scope of Practice:

• Registered Nurse
• Paramedic
• Community Paramedic

Route(s):

• IO, IV,

Pharmacodynamics (class and mechanism of action):

• Antihypertensive (Alpha and beta blockade. Binds with α1 (alpha-1), β1 (beta-1), and β2 (beta-2) receptors in vascular smooth muscle. Inhibits strength of heart’s contractions and rate.).

Pharmacokinetics:

• Half-life: 5.5 hours.
• Onset time: 2-5 minutes.
• Peak action time: 5 minutes.
• Duration of action: 2-4 hours.

• Peak	18	36	54	72	90	108	126	144	162	180	198	minutes
  Duration	18	36	54	72	90	108	126	144	162	180	198	minutes

Dosing:

• Refer to specific protocol(s) below for dose(s).

Indications:

• Protocol 2-528 - Hypertension.

Contraindications:

• Bronchial Asthma.
• Heart block.
• Cardiogenic shock.
• Bradycardia.
• Hypotension.
• Pulmonary Edema.
• Heart failure.
• Sick Sinus Syndrome.

Pregnancy Risk Factor:

• Category C
• Risk not ruled out: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. FDA requires a relatively large amount of high-quality data on a pharmaceutical for it to be defined as Pregnancy Category A. As a result of this, many drugs that would be considered Pregnancy Category A in other countries are allocated to Category C by the FDA.

Potential Incompatibilities:

• Medication 7-360 - Lasix.

Precautions and Adverse Effects:

• Blood pressure should be constantly monitored.
• Cannot give at the same time with Lasix.
• May cause dizziness, flushing, Nausea, Vomiting, headaches, weakness, postural hypotension, hypotension, Bronchospasm, arrhythmia, Bradycardia, AV block

Antidote:

• Medication 7-329 - Epinephrine.
• Medication 7-384 - Glucagon.

Controlled Substance Information:

• Not a scheduled drug
• The DEA and FDA have not identified this drug with a schedule classification.
• DEA number: NA.
• Narcotic: No.
• Street names: NA.

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CMH Mobile Integrated Healthcare Mission: "Provide exceptional, compassionate, and patient-centered care by a mobile collaborative team to improve patient experience, improve quality outcomes, and reduce healthcare costs."

Polk, Hickory, Cedar, & St Clair County EMS Protocols is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.