Medication 7-921 - TXA (Tranexamic Acid)

CMH EMS & MIH Protocols

Scope of Practice:

• Registered Nurse
• Paramedic
• Community Paramedic

Route(s):

• IO, IV,

Pharmacodynamics (class and mechanism of action):

• Antifibrinolytic. (Synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the lysine binding sites on plasminogen.)

Pharmacokinetics:

• Half-life: 2 hours.
• Onset time: 5-15 minutes.
• Peak action time: Unknown.
• Duration of action: 3 hours.

• Peak	18	36	54	72	90	108	126	144	162	180	198	minutes
  Duration	18	36	54	72	90	108	126	144	162	180	198	minutes

Dosing:

• Refer to specific protocol(s) below for dose(s).

Indications:

• Protocol 2-451 - General Trauma Management.

Contraindications:

• Age less than 16 years.
• Renal failure.
• Hypersensitivity.
• History of thromboembolism.
• Known subarachnoid aneurysm.
• Injury greater than three (3) hours old.
• Isolated Head Injury.
• Colorblindness.

Pregnancy Risk Factor:

• Category B
• No risk in other studies: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women, or animal studies have shown adverse effects, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Potential Incompatibilities:

• None.

Precautions and Adverse Effects:

• Rapid infusion may cause hypotension. If hypotension occurs, slow down infusion rate.
• If TXA is administered, transport destination must be a level I, level II, or level III trauma center.
• Avoid concurrent use with coagulation factors.
• Use caution in patients with DIC.
• Use caution in patients with renal impairment.
• May cause visual defects, Seizures, Nausea, Vomiting, and/or diarrhea.

Antidote:

• None.

Controlled Substance Information:

• Not a scheduled drug
• The DEA and FDA have not identified this drug with a schedule classification.
• DEA number: NA.
• Narcotic: No.
• Street names: NA.

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Polk, Hickory, Cedar, & St Clair County EMS Protocols is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.